1. Introduction
The hypothesis of cancer stem cells (CSCs) was proposed for the root time for nearly a century ago. However, most of the weight unit in cancer research was initially non centre on this particular atomic number 18a for the treatment of cancer and it was non until recently the focus has shifted towards CSCs, due to the identification of stem cell subcomponents that has been found in a number of human malignancies. For object lesson they have been found in hematologic malignant tumour and tumours in prostate, breast, brain, pancreas and a few other tissues/organs (Korkaya & Wicha, 2007; Al-hajj et al, 2003). (However account up on Li et al, 2007 saying that pancreatic csc was not found). However another study that was done by Li during 2007 pancreatic cancer stem cells was not found. CSCs are a subset of malignant cell found in hierarchically organized tumors and hematological cancers, in which secern are suggesting that they contain stem cell deal properties that includes self-renewal and differentiation (Schatton et al, 2009 and Korkaya & Wicha, 2007). Hence the name CSCs and are sometimes considered as the origin of tumorigenic cells, because of its stem cell like properties it has the ability to constitutively activate survival pathways and proliferate indefinitely (Eramo et al, 2007).
This writings review will be looking at the evidence showing the theory of CSC existence as well as the evidence disapproving the existence of CSCs. We will also be looking at the implications of using conventional cancer therapy from the CSC positioning and finally what opportunities the theory of CSC can provide for the treatment and diagnosing of cancer in modern days.
2. Stem cells
Stem cells can be defined as undifferentiated cells that are open(a) of self-renewing and differentiating into a large number of diverse mature proceeds (Gua et al, 2006). There are several different types of stem cells such(prenominal) as, the embryonic stem cell (ESC) which has the ability...If you want to get a full essay, order it on our website: Orderessay
If you want to get a full essay, wisit our page: write my essay .
No comments:
Post a Comment